Cramer rules with extensions: This plug-in is a copy of the original plug-in, plus minor extensions. Like the Cramer plug-in, this plug-in works by assigning compounds to Class I, II, or III, according to the rules from Cramer, and some extra ones. Several compounds were classified by Munro in 1996 as Class I or Class II compounds according to the Cramer rules, even though Munro reported low NOEL values upon oral administration (indicating relatively high toxicity). To overcome such misclassifications, five rules have been introduced to capture the possible toxicity of these compounds;
Available since ToxTree 1.60
This module is extending the original Cramer scheme with additional 5 questions (Q40-44) addressing functional groups such as phosphates, benzene-like substances, divalent sulphurs and unsaturated heteroatom moieties.
<dependency> <groupId>toxtree</groupId> <artifactId>toxtree-cramer2</artifactId> <version>2.5.8</version> </dependency>
<repository> <id>ambit-plovdiv-releases</id> <url>http://ambit.uni-plovdiv.bg:8083/nexus/content/repositories/releases</url> </repository>