Cramer rules (Cramer G. M., R. A. Ford, R. L. Hall, Estimation of Toxic Hazard - A Decision Tree Approach, J. Cosmet. Toxicol., Vol.16, pp. 255-276, Pergamon Press, 1978);

Developed by IdeaConsult Ltd., (Sofia, Bulgaria) for EC Joint Research Centre, Computational Toxicology

Screenshots: Main screen , Decision tree, Decision tree visualisation

Applicability of Cramer rules Toxtree module

The Toxtree implementation of the Cramer scheme can, in principle, be applied to organic molecules, organic salts and organometallics, and structurally well-defined oligomers and polymers.

With regards to oligomers and polymers: Despite there is no technical limitation in Toxtree in running oligomers and polymers (assuming their structures are well defined), these substances are generally considered out of scope of the Cramer scheme since they were not present in the dataset from which the scheme was derived [Cramer, 1978], with the exception of substances containing a polyoxyethylene [(- OCH2CH2-)x, with x no greater than 4] chain (cf. questions 20 and 32).


Cramer, 1978
Cramer GM, Ford RA, Hall RL (1978) Estimation of Toxic Hazard - A Decision Tree Approach. J. Cosmet. Toxicol. 16, 255-276.
Patlewicz, 2008
Patlewicz G, Jeliazkova N, Safford RJ, Worth AP, Aleksiev B. (2008) An evaluation of the implementation of the Cramer classification scheme in the Toxtree software. SAR QSAR Environ Res. ;19(5-6):495-524.
Lapenna 2011
Lapenna S & Worth A (2011), Analysis of the Cramer classification scheme for oral systemic toxicity - implications for its implementation in Toxtree. EUR 24898 EN. Publications Office of the European Union, Luxembourg.

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Version: 3.0.2-SNAPSHOT. Last Published: 2017-09-27.